The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization
نویسندگان
چکیده
منابع مشابه
Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle
De novo hair follicle formation in embryonic skin and new hair growth in adult skin are initiated when specialized mesenchymal dermal papilla (DP) cells send cues to multipotent epithelial stem cells. Subsequently, DP cells are enveloped by epithelial stem cell progeny and other cell types to form a niche orchestrating hair growth. Understanding the general biological principles that govern the...
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While intelligent-design proponents enjoy their 15 minutes of fame denying the role of evolutionary forces in generating complex networks in nature, scientists are probing the organizing principles that govern these networks. Traditional models of complex networks assumed that connections between units—such as genes, proteins, neurons, or species—occur randomly. These notions changed as studies...
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Hedgehog (Hh) signaling has been implicated in the development of osteoblasts and osteoclasts whose balanced activities are critical for proper bone formation. Since many mouse mutants in the Hh pathway are embryonic lethal, questions on the exact effects of Hh signaling on osteogenesis remain. Using zebrafish larvae mutant in Indian Hedgehog, patched1, patched2 and suppressor of fused (dre), w...
متن کاملPrinciples and mechanisms of regeneration in the mouse model for wound‐induced hair follicle neogenesis
Wound induced hair follicle neogenesis (WIHN) describes a regenerative phenomenon in adult mammalian skin, wherein fully functional hair follicles regenerate de novo in the center of large excisional wounds. Originally described in rats, rabbits, sheep, and humans in 1940-60, the WIHN phenomenon was reinvestigated in mice only recently. The process of de novo hair regeneration largely duplicate...
متن کاملEstablishment of human hair follicle mesenchymal stem cells with overexpressed human hepatocyte growth factor
Objective(s): Chronic liver disease has become a major health problem that causes serious damage to human health. Since the existing treatment effect was not ideal, we need to seek new treatment methods. Materials and Methods: We utilized the gene recombination technology to obtain the human hair mesenchymal stem cells which overexpression of human hepatocyte growth factor (hHGF). Furthermore, ...
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ژورنال
عنوان ژورنال: Experimental Dermatology
سال: 2010
ISSN: 0906-6705,1600-0625
DOI: 10.1111/j.1600-0625.2009.00935.x